Cysteine-rich cationic peptide with antiviral activity against HSV infection and a role in N. gonorrhoeae-mediated HIV enhancement. In contrast to the other members of the ƒ-defensin family it shows very low antimicrobial activity against Gram-negative and Gram-positive bacteria. As a biomarker of colon adenocarcinoma it may have utility in colon cancer screening and diagnosis.
M.E.Klotman et al., J. Immunol., 180, 6176 (2008) A.Szyk et al., Protein Sci., 15, 2749 (2006) E.Hazrati et al., J. Immunol., 177, 8658 (2006) M.J.Nam et al., J. Biol. Chem., 280, 8260 (2005) Z.Wu et al., J. Pept. Res., 64, 118 (2004)
Sequence (One-Letter Code)
AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL (Disulfide bonds between Cys⁴ and Cys³¹/Cys⁶ and Cys²⁰/Cys¹⁰ and Cys³⁰)
Sequence (Three-Letter Code)
H-Ala-Phe-Thr-Cys-His-Cys-Arg-Arg-Ser-Cys-Tyr-Ser-Thr-Glu-Tyr-Ser-Tyr-Gly-Thr-Cys-Thr-Val-Met-Gly-Ile-Asn-His-Arg-Phe-Cys-Cys-Leu-OH (Disulfide bonds between Cys⁴ and Cys³¹/Cys⁶ and Cys²⁰/Cys¹⁰ and Cys³⁰)