Alloferon 1, a member of the Alloferons is extracted from the blood of experimentally infected Callifora vicina fly and demonstrates both antimicrobial and anti-tumour activity . The Alloferons are bioactive, cationic peptides and exhibit the ability to stimulate Natural Killer cell activity and IFN synthesis. Due to studies investigating the effect Alloferon 1 would have on the central nervous system it was shown that Alloferon 1 had no toxic effects and therefore has the potential to be used as an anti-tumour therapeutic.
Rykaczewska-Czerwińska et al (2015) Effect of alloferon 1 on central nervous system in rats. Acta Pol. Pharm. 72(1) 205 PMID: 25850216 Chernysh et al (2002) Antiviral and antitumor peptides from insects. Proc. Natl. Acad. Sci. 99 (20) 12628 DOI: https://doi.org/10.1073/pnas.192301899