CRAMP-18 is the anti-bacterial sequence derived from CRAMP, it possesses potent anti-bacterial activity against Gram-positive and Gram-negative bacterial strains with no haemolytic activity. As well as displaying direct anti-microbial activity, CRAMP-18 also binds to lipopolysaccharide (LPS) to neutralise LPS activity.
Horibe et al (2013) Roles of cathelicidin-related antimicrobial peptide in murine osteoclastogenesis. Immunology 40(3) 344 PMID: 23826736 Wertenbruch et al (2015) The Anti-Microbial Peptide LL-37/CRAMP Is Elevated in Patients with Liver Diseases and Acts as a Protective Factor during Mouse Liver Injury. Digestion 91(4) 307 PMID: 25998843