| Product Name | Defensin 5 (human) |
| Purity | HPLC>95% |
| Description | Human defensin-5 (HD 5) is a key regulator of gut microbiota homeostasis. HD 5 exhibits microbicidal activity against bacteria, fungi, and viruses and is released by Paneth cells in the small intestine. Reduction or absence of HD 5 release in the intestinal mucosa has been associated with susceptibility to enteric pathogens, changes in composition of the microbiota, and disruption of intestinal immune homeostasis. As a biomarker, HD 5 might be used to distinguish between ulcerative colitis (low levels of HD 5) or Crohn's colitis (high levels of HD 5). |
| Storage | -20°C |
| References | A.D. Williams et al., PLoS One, 12, e0179710 (2017) L. Furci et al., Infect. Immun., 83, 986 (2015) |
| Molecular Weight | 3582.18 |
| Sequence (One-Letter Code) | ATCYCRTGRCATRESLSGVCEISGRLYRLCCR |
| Sequence (Three-Letter Code) | H-Ala-Thr-Cys-Tyr-Cys-Arg-Thr-Gly-Arg-Cys-Ala-Thr-Arg-Glu-Ser-Leu-Ser-Gly-Val-Cys-Glu-Ile-Ser-Gly-Arg-Leu-Tyr-Arg-Leu-Cys-Cys-Arg-OH (Disulfide bonds, air oxidized) |
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