Histatin-5 is a cleavage product representing the N-terminal 24 amino acids of histatin-3. Histatins are strong antifungal agents and histatin-5 has the highest activity against pathogenic fungi, such as Candida species. Histatin-5 contains an N-terminal copper and nickel (ATCUN) binding motif which can generate reactive oxygen species which have important roles in histatins antifungal activity. Histatins are also involved in wound healing in the oral cavity.
Blotnick et al (2017) Interactions of histatin-3 and histatin-5 with actin. BMC Biochem. 18(1) PMID: 28264651