Keratin-Derived anti-microbial Peptides (KDAMPs), are peptide fragment of the intermediate filament protein cytokeratin 6A. They were originally isolated from lysates of human corneal epithelial cells. KDAMPs exhibit coil structures with low α-helical content and are smaller and more stable than other known host-expressed anti-microbials.
Tam et al (2012) Cytokeratins mediate epithelial innate defense through their antimicrobial properties. J. Clin. Invest. 122(10) 3665 PMID: 23601656