NRC-16, is a 19 amino acid cationic peptide, derived from witch flounder.1 NRC-16 shows a potent inhibitory effect against Gram-negative bacteria, Gram-positive bacteria and fungi.2,3 When tested for antibiofilm activity with P. aeruginosa strains NRC-16 inhibited biofilm formation with no cytotoxic effects. Since NRC-16 displays antimicrobial and antibiofilm activities with less cytotoxicity, it can be considered for treatment of microbial infections in the future.
1. Gopal R. et al., Mar Drugs 11,1836-52 (2013) 2. Patrzykat A. et al., Antimicrob. Agents Chemother. 47:2464–2470 (2003) 3. Gopal R. et al., Int. J. Mol. Sci. 13:3229–3244 (2012)
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Gly - Trp - Lys - Lys - Trp - Leu - Arg - Lys - Gly - Ala - Lys - His - Leu - Gly - Gln - Ala - Ala - Ile - Lys - OH