Acetyl-Alpha-synuclein (1-13) Met1(O), Met5(O) Heavy
Acetylated α-synuclein (1-13) is derived from the alpha-synuclein intrinsically disordered protein which is found in the neurons and presynaptic terminals. Encoded by the SNCA1/PARK1 gene alpha-synclein is structurally composed of 140 amino acids, making up the three domains: N-terminal membrane binding domain, a hydrophobic non-amyloid-beta component domain and a hydrophilic C-terminal domain. Usually alpha-synuclein plays a role in protecting neurons from apoptotic stimuli and is involved in synaptic vesical trafficking.
Binolfi et al (2016) Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites. Nat. Commun. 7 10251 https://doi.org/10.1038/ncomms10251
Sequence (One-Letter Code)
Ac-[Met(O)]-DVF-[Met(O)]-KG-[U-13C6,15N-Leu]-SKAKE-acid, where Met(O) is oxidised Methionine