This is amino acids 1 to 12 fragment of the beta-amyloid peptide. This N-terminal sequence was used to develop the antibody BR88. An antiserum directed against this peptide stained numerous tangle-bearing cells and bodies, as well as the neuritic component of plaques and neuropil threads. It stained a large number of pyramid cells.
Spillantini, M. et al. Proc. Natl. Acad. Sc. 87, 3947 (1990).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - OH