[NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22-27)Admin2020-12-18T13:21:32+00:00
[NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22-27)
This amino acids 22 to 27 fragment is a modification of the human islet amyloid polypeptide hIAPP (NFGAIL) with N-methylation of the amide bonds at G24 and I26. The introduction of two N-methyl rests in the amyloid-core-containing sequence NFGAIL converts this amyloidogenic and cytotoxic sequence into non-amyloidogenic and non-cytotoxic peptide. The peptide is able to bind with high-affinity full-length hIAPP and to inhibit its fibrillogenesis.
Yan, L. et al. PNAS 103, 2046 (2006), Kapurniotu, A., et al. J. Mol. Biol. 315, 339 (2002), Tatarek-Nossol, M. et al. Cell Press 12, 797 (2005).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Asn - Phe - (NMe - Gly) - Ala - (NMe - Ile) - Leu - OH