This peptide is derived from Aβ (12-28), which represents a binding site for apolipoprotein E (apoE). apoE is a genetically inherited risk factor for Alzheimer’s disease that promotes aggregation of toxic Aβ. Substitution of Val18 to proline competitively
Sadowski, M. et al. Am J Pathol 165, 937 (2004).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Val - His - His - Gln - Lys - Leu - Pro - Phe - Phe - Ala - Glu - Asp - Val - Gly - Ser - Asn - Lys - OH