Pyroglutamyl β-Amyloid (4-14) Biotin is derived from Amyloid-β, which has been identified as the key subunit of the extracellular plaques found in the brains of patients with Alzheimer’s disease (AD) and Down’s syndrome (DS).
Masters and Selkoe (2012) Biochemistry of Amyloid -Protein and Amyloid Deposits in Alzheimer Disease. Cold Spring Harb. Perspect. Med. 2(6) a006262 PMID: 22675658
Sequence (One-Letter Code)
[pGlu]-FRHDSGYEVHH-Biotin, biotin is C-terminally linked to the peptide via ethylenediamine, and [pGlu] is pyroglutamate