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(Val³⁴)-Amyloid β-Protein (1-40)

Home/Beta Amyloid Peptides/(Val³⁴)-Amyloid β-Protein (1-40)
(Val³⁴)-Amyloid β-Protein (1-40)Admin2020-12-18T11:53:03+00:00
Product Name (Val³⁴)-Amyloid β-Protein (1-40)
Purity HPLC>95%
Description Cerebral amyloid angiopathy (CAA) is a common finding in Alzheimer’s disease in which amyloid-Aβ vascular deposits are featured in >80% of the cases. Mutations in the positions 21-23 (e.g. Dutch mutation E22Q) are primarily associated with CAA, although they manifest with strikingly different clinical phenotypes: cerebral hemorrhage or dementia. The Piedmont L34V Aβ mutant, located outside this hot spot, shows a similar hemorrhagic phenotype, albeit less aggressive than the widely studied Dutch variant.
Storage -20°C
References S.Fossati et al., FASEB J., 24, 229 (2010) L.Obici et al., Ann. Neurol., 58, 639 (2005)
Molecular Weight 4315.84
Sequence (One-Letter Code) DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGVMVGGVV
Sequence (Three-Letter Code) H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Val-Met-Val-Gly-Gly-Val-Val-OH

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