This peptide is derived from residues 31-43 of gliadin wheat protein. It induces innate immune response by up-regulating the expression of interleukin (IL)-15 and cyclooxygenase (COX)-2. This peptide also promotes the expression of CD25 in monocytes and macrophages, the expression of CD83 in dendritic cells, and the activation of p38 MAP kinase. Treatment with this peptide can induce immunodominant epitopes (57-68 and 62-75) to induce T cell activation and intestinal cell apoptosis.
Chambers, S. et al. Anal Biochem 292, 301 (2001). Maiuri, L. et al. Lancet 362, 30 (2003). Mamone, G. et al. J Chromatogr B 855, 236 (2007).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Leu - Gly - Gln - Gln - Gln - Pro - Phe - Pro - Pro - Gln - Gln - Pro - Tyr - OH