The tripeptide is an alpha factor pheromone of Saccharomyces cerevisiae, which induces yeast binding by binding to Ste2p, and its homologous GPCR activates a G protein signaling pathway that is highly conserved with mammalian signaling pathways.
Lee, BK. et al. J. Biol. Chem. 276, 37950 (2001); Mayrhofer, S. and S. Pöggeler Eukaryot. Cell 4, 661 (2005).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Trp - His - Trp - Leu - Gln - Leu - Lys - Pro - Gly - Gln - Pro - Met - Tyr - OH