The peptide is derived from residues 14-21 of protein kinase C C2 (epsilon pkcc2). The peptide specifically inhibits epsilon PKC by destroying the binding of PKC to its receptor Rack2. Epsilon PKC mediated signal transduction plays a role in cell proliferation, differentiation and apoptosis.
Lamy, C. et al. Tetrahedron Lett 46, 6177 (2007). Brandman, R. et al. J. Biol. Chem. 282, 4113 (2007).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Glu - Ala - Val - Ser - Leu - Lys - Pro - Thr - OH