This peptide corresponds to the GAP27 domain of the second extracellular loop of dominant vascular connexin (Cx40), designated as 40Gap 27. It was used to investigate mechanisms through which oxidant stress impairs communication via gap junctions. When administered, 40Gap27attenuates endothelium-dependent subintimal smooth muscle hyperpolarization.
Chaytor, A. et al. British J. Pharmacol. 144, 108 (2005).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Arg - Pro - Thr - Glu - Lys - Asn - Val - Phe - Ile - Val - OH