ACTH (1–17), and aMSH (a-Melanotropin), both derived from POMC (proopiomelanocortin) are involved in melanogenesis. However, ACTH (1-17) has been found to be more potent in malanogenesis in human malanocytes. Both ACTH (1-17) and aMSH also increase dendricity, and proliferation in follicular melanocytes.
Kauser, S. et al. FASEB J 20, 882 (2006) Tsatmali, M. et al. Cell Mol Bio 45, 1029 (1999)
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Tyr - Ser - Met - Glu - His - Phe - Arg - Trp - Gly - Lys - Pro - Val - Gly - Lys - Lys - Arg - OH