This ACTH (18-39) fragment is known as the Corticotropin-like Intermediate Lobe Peptide. It stimulates insulin secretion as well as amylase and protein secretion in a dose-dependent manner similar to those of secretin and carbamylcholine.
Scott, AP. et al. J. Endocrinol. 61, 355 (1974); Bellingham, NA. et al. J. Endocrinol 94, 125 (1982); Marshall, JB. et al. J. Clin. Invest. 74, 1886 (1984); Zaphiropoulos, A. et al. Brain Res. Bull. 26, 99 (1991)
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Arg - Pro - Val - Lys - Val - Tyr - Pro - Asn - Gly - Ala - Glu - Asp - Glu - Ser - Ala - Glu - Ala - Phe - Pro - Leu - Glu - Phe - OH