This peptide is a capsid-derived immunodominant adeno-associated virus 2 (AAV2), cd8t cell epitope. The hepatotoxicity of systemic inoculation of AAV2 in hemophilia patients observed in a clinical trial was due to the killing of vector-transduced liver cells by capsid-specific T cells.
Murphy, S. et al. Blood (ASH Annual Meeting Abstracts), 108 (2006), Mingozzi, F. et al. Nature Medicine 10.1038/nm1549 (2007), Wang, L. et al. Therapy. 18, 185 (2007).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Val - Pro - Gln - Tyr - Gly - Tyr - Leu - Thr - Leu - OH