Angiotensin II SubstrateAdmin2021-01-04T11:08:23+00:00
Angiotensin II Substrate
This is a tyrosine phosphorylated angiotensin II peptide with a substrate sequence specificity for chymase to act. This is an octapeptide hormone that is formed as a result of the action of human heart chymase, a chymotrypsin-like serine protease on the Phe-His bond of Angiotensin I. The ideal susbtrate for human heart chymase should contain this peptide sequence, and has been demonstrated that the Pro-Phe sequence in P2-P1 positions of peptide substrates is highly favored by leukocyte chymotrypsin-like proteinases such as chymases and cathepsin G.
1, Kinoshita A, et al. J Biol Chem 266(29): 19192-19197 (1991). 2, Ruzzene, M. et al. Eur. J. Biochem. 211, 289 (1993).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Asp - Arg - Val - pTyr - Ile - His - Pro - Phe - OH