The peptide is a fragment of human aquaporin-2 (AQP2) phosphorylated at ser261. Protein phosphorylation plays a key role in vasopressin signal transduction in renal collecting duct. Several phosphorylation residues, including ser261256, are altered in response to pressure. Both sites may be involved in AVP dependent AQP2 trading.
Nielsen, S. et al. PNAS 90, 11663 (1993); Hoffert, J. et al. PNAS 103, 7159 (2006).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Arg - Gln - Ser - Val - Glu - Leu - His - pSer - Pro - Gln - Ser - Leu - Pro - Arg - OH