This tumor antigenic peptide presented by HLA-A2 antigen to CTLs, is a tyrosinase fragment. Tyrosinase is a membrane-bound protein involved in the melanin synthesis pathway that is expressed by virtually all primary melanoma lesions and by most of metastatic lesions.
Chapiro, J. et al. J. Immunol. 176, 1053 (2006); Paczesny, S. et al. JEM 199, 1503 (2004); Lee, P. et al J. Clin. Oncol. 19, 3836 (2001).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Tyr - Met - Asp - Gly - Thr - Met - Ser - Gln - Val - OH