The transgenic TCR model (BDC2.5) mimitope was applied to the study of type 1 diabetes (T1D). T1D is an autoimmune disease. T cells mediate pancreatic islet cell apoptosis. T1D is caused by autoreactive T cells destroying insulin-producing cells. Using BDC2.5 mimotope to study the effect of antigen peptides on islet autoantigen-specific T cells
Hu, C. et al. J. Clin. Invest. 117, 3857 (2007); Martin-Orozco, N. et al. J. Immunol. 171, 6954 (2003).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Arg - Thr - Arg - Pro - Leu - Trp - Val - Arg - Met - Glu - OH