A highly modified luteinizing hormone releasing hormone (LHRH) decapeptide with a terminal amide group and is an LHRH antagonist. Regulate the expression of Galphas and Galphai protein subunits and the activity of adenylate cyclase in the ovary, breast and pituitary. Cetrarelil competitively inhibits pituitary LHRH receptors and inhibits ovarian and testicular functions.
Ref: Collado, B. et al. Intl. J. Oncol. 24, 725 (2004); Schwahn, M. et al. Drug Metabolism and Disposition. 28, 10 (2000).