The peptide is histone H3 (1-21), which is deamination at Arg17 and converted to Cit (citrulline). It is biotinylated via the C-terminal GGK connector. Peptidyl arginine deaminase 4 (PADI4) deamination can block CAM1 methyltransferase methylation and inhibit transcription activation. With a peptide purity greater than 95%, the peptide is dissolved in distilled water at 1 mg/ml, and then lyophilized into a powder.
Cuthbert, G. et al. Cell 118, 545 (2004).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Arg - Thr - Lys - Gln - Thr - Ala - Arg - Lys - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Cit - Lys - Gln - Leu - Ala - Gly - Gly - Lys(Biotin) - OH