This peptide is histone H4 (1-23), deaminated at Arg3. There is a biotinylated C-terminal GGK linker on the side chain of lysine. Arginine Arginine Deaminase (PADI)-4 deaminates arginine. Although the function of deamination is unclear, it has been shown to inhibit arginine methylation and inhibit nuclear hormone receptor-dependent gene activation. When the peptide purity is greater than 95%, the peptide is dissolved in distilled water at a concentration of 1 mg/ml, and lyophilized again into a powder form.
Hagiawara, T. et al. Biochem 44, 5827 (2005).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Gly - Cit - Gly - Lys - Gly - Gly - Lys - Gly - Leu - Gly - Lys - Gly - Gly - Ala - Lys - Arg - His - Arg - Lys - Val - Leu - Arg - Gly - Gly - Lys(Biotin) - OH