The dimer of CKS-17 has a naturally-occurring cysteine at the carboxy terminus (which is present in the retroviral peptide on which CKS-17 is based), and dimerizes through a cysteine-disulfide bond 化. CKS-17 is a synthetic retroviral envelope hepeptide, which corresponds to a highly conserved region in retroviral transmembrane proteins (such as pl5E). It has previously been shown that the CKS-17 peptide can inhibit the inactivation of interleukin 1, thereby inhibiting monocyte superoxide production, natural killer cell activity, polyclonal B cell activation and monocyte-mediated killing.
Nelson, M. et al. Cancer Immunol Immunother 30, 113 (1989).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Leu - Gln - Asn - Arg - Arg - Gly - Leu - Asp - Leu - Leu - Phe - Leu - Lys - Glu - Gly - Gly - Leu - Cys - OH