This peptide is the second complement component (C2), the physiological substrate of the proenzyme Cls, the first complement component. The complement system is a central component of host defense, but it can also cause inflammation in pathological conditions. The C1s protease of the C1 complex initiates the host defense pathway. The peptide uses 2Abz/Dnp-FRET pair to quantitatively analyze complement enzyme activity
Kerr, F. et al. J. Biol. Chem. 280, 39510 (2005), S. Nagasawa, and R. Stroud PNAS 74, 2998 (1977).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
2Abz - Ser - Leu - Gly - Arg - Lys - Ile - Gln - Ile - Lys(Dnp) - NH2