Crosstide is a peptide analog of glycogen synthase kinase 3 (GSK-3) and a natural substrate of Akt/PKB. It shows similar specificity for PKBα, PKBβ and PKBγ subtypes. It is also recognized by MAPKAP kinase-1 and p70S6K. Fluorescent peptide and biotin peptide show similar enzymatic activity
Ref: Dai, F. et al. Biochem. Biophys. Res. Commun. 293, 1191 (2002). Meier, R. et al. J. Biol. Chem. 272, 30491 (1997); Chan, TO. et al. Ann. Rev. Biochem. 68, 965 (1999).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
5 - FAM - Gly - Arg - Pro - Arg - Thr - Ser - Ser - Phe - Ala - Glu - Gly - OH