This 21 residue peptide (ET-3) is a member of a family of potent vasoconstrictors namely, Endothelin and Sarafotoxin. ET-3 is a less potent vasoconstrictor than ET-1 also varying by 6 amino acids in sequence homology.
Mills RG. et al. Biochem, 31: 5640-5645 (1992).
Sequence (One-Letter Code)
CTCFTYKDKECVYYCHLDIIW (Disulfide bridge: 1-15 and 3-11)
Sequence (Three-Letter Code)
H - Cys - Thr - Cys - Phe - Thr - Tyr - Lys - Asp - Lys - Glu - Cys - Val - Tyr - Tyr - Cys - His - Leu - Asp - Ile - Ile - Trp - OH (Disulfide bridge: 1 - 15 and 3 - 11)