This peptide is a specific inhibitor of εPKC. Its inhibitory activity is based on εPKC translocation and MARCKS phosphorylation. This peptide interferes with the interaction of εPKC with the anchor protein εRACK. The peptide contains a cysteine residue added to the C-terminus, which can form a potential S-S bond with the carrier protein
Johnson, J. et al. J. Biol. Chem. 271, 24962 (1996), Brandman, R. et al. J. Biol. Chem. 282, 4113 (2007).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Glu - Ala - Val - Ser - Leu - Lys - Pro - Thr - Cys - OH