GIP (glucose-dependent insulinotropic polypeptide, also known as gastric inhibitory polypeptide) is a 42 amino acid peptide released by K cells in the duodenum and jejunum after eating. GIP and GLP (gastric-like peptides) are members of the incretin hormone peptide family, which can stimulate pancreatic β-cells to secrete insulin, and promote β-cell proliferation and β-cell survival. Recent studies have shown that GIP plays a role in lipid homeostasis and may play a role in the pathogenesis of obesity.
Brown, JC & JR Dryburgh Can J Biochem 49, 867 (1971), doi: 10.1139/o71-122 Buchan, MT. et al. Histochem 56, 37 Dupre, J. et al. J Clin Endocrinol Metab 37, 826 (1973), doi: http://dx.doi.org/10.1210/jcem-37-5-826 Getty-Kaushik, L. et al. Obesity 14, 1124, doi: 10.1038/oby.2006.129
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Tyr - Ala - Glu - Gly - Thr - Phe - Ile - Ser - Asp - Tyr - Ser - Ile - Ala - Met - Asp - Lys - Ile - His - Gln - Gln - Asp - Phe - Val - Asn - Trp - Leu - Leu - Ala - Gln - Lys - Gly - Lys - Lys - Asn - Asp - Trp - Lys - His - Asn - Ile - Thr - Gln - OH