In small intestinal L cells, proglucagon is cleaved into GLP-1 (1-36) due to glucose uptake. Before secretion into the circulation, GLP-1 (1-36) is further processed into amidated GLP-1 (7-36) and a small amount of glycine-extended GLP-1 (7-37). Both GLP-1(7-36) and GLP-1(7-37) can cause glucose-dependent release of insulin by pancreatic cells. They also inhibit gastric motility (gastric emptying), suppress plasma glucagon levels (glucose production), and may play a role in promoting satiety and stimulating glucose processing in peripheral tissues, independent of insulin. GLP-1 polypeptides such as GLP-1 (1-36) have been used to study the recovery of pancreatic cell function. GLP-1 is also produced in the central nervous system
Drucker, D. et al. Proc Natl Acad Sci USA 84, 3434 (1987) Kieffer, T. and J. Habener, Endo Rev 20, 876 (1999) Deacon, CF. et. al. Hormone Metabolic Res 36,761 (2004), doi: 10.1055/s-2004-826160 Williams, JA. Pancreadepedia (2014), doi: 10.3998/panc.2014.7.
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - His - Asp - Glu - Phe - Glu - Arg - His - Ala - Glu - Gly - Thr - Phe - Thr - Ser - Asp - Val - Ser - Ser - Tyr - Leu - Glu - Gly - Gln - Ala - Ala - Lys - Glu - Phe - Ile - Ala - Trp - Leu - Val - Lys - Gly - Arg - NH2