This is a 524 to 543 amino acid fragment of glutamate decarboxylase 65 (GAD65). In non-obese diabetes (NOD) mice spontaneous autoimmune diabetes (NOD) model, it is the first fragment of the pancreatic islet antigen, which can induce proliferative T cell responses. This peptide is a specific stimulator of the spontaneously produced diabetic T cell clone BDC2.5, and may be a low-affinity stimulator. Immunization with p524-543 can increase the susceptibility of NOD mice to type 1 diabetes induced by adoptive transfer of BDC2.5t cells.
Quinn, A. et al. J. Immunol. 166, 2982 (2001); Dai, Y. et al. J. Immunol. 175, 3621 (2005).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Arg - Leu - Ser - Lys - Val - Ala - Pro - Val - Ile - Lys - Ala - Arg - Met - Met - Glu - Tyr - Gly - Thr - Thr - OH