This is amino acids 25 to 33 fragment of human melanoma antigen gp100. This H-2Db restricted epitope is recognized by T cells. The gp100-specific, H-2Db-restricted, CD8+ T cells are capable of recognizing B16 melanoma but not normal melanocytes. This peptide was used as an immunogen in multiple cancer immunotherapy studies.
Overwijk, W. et al. J. Exp. Med. 188, 277 (1998), Wang, L. Cancer Res. 65, 10569 (2005), Finkelstein, S. et al. J. Leukoc. Biol. 76, 333 (2004).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Lys - Val - Pro - Arg - Asn - Gln - Asp - Trp - Leu - OH