This is amino acids 54 to 65 fragment of sulfated hirudin, a 65-residue peptide. Hirudin is found in the saliva of the leech Hirudo medicinalis. This sulfated peptide binds tightly to anion-binding exosite I of thrombin, but does not inhibit hydrolysis of synthetic peptide substrates.
Van Deerlin, V. et al. J. Biol. Chem. 266, 20223 (1997).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
Ac - Gly - Asp - Phe - Glu - Glu - Ile - Pro - Glu - Glu - Tyr(SO3H) - Leu - Gln - OH