This is a 1 to 20 amino acid fragment of histone H3. Comparing the acetylation efficiency of different substrates, it is found that the peptide corresponding to the N-terminus of H3 histone has almost the same acetylation efficiency as the H4 peptide. Acetylation of histones is usually associated with active transcription, constituting a post-translational marker recognized by specific chromatin factors, and has been proven in vitro to prevent salt-induced nucleosome array folding. The multi-subunit histone acetyltransferase (HAT) complex recognizes and performs an effective acetylation reaction on the nucleosome substrate.
Berndsen, C. et al. Biochem. 46, 2091 (2007).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Arg - Thr - Lys - Gln - Thr - Ala - Arg - Lys - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - OH