This sequence is a 1 to 21 amino acid fragment of histone 4. Histone acetyltransferase (HAT) p300/CBP catalyzes the acetylation of free histone H4 at the N-terminus of Lys5, 8, 12, and 16. It is believed that acetylation in H8 is the first choice. The determinant of the interaction between p300 and histone 4 seems to be entirely in the N-terminal region of the H4-21 protein.
Sun, Y. et al. Mol. Cell. Biol. Oct 2007, 10.1128/MCB.01382-07.
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Gly - Arg - Gly - Lys - Gly - Gly - Lys - Gly - Leu - Gly - Lys - Gly - Gly - Ala - Lys - Arg - His - Arg - Lys - Val - OH