This peptide is a fragment of JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most obvious ligand expressed in the skin. JAG-1 induces epidermal maturation. In the presence of elevated calcium concentration, exposure of the submerged keratinocyte monolayer to JAG-1 produces stratification with loricrin expression and NF-κB activation.
Nickoloff, B. et al. Cell Death Different. 9, 842 (2002).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Cys - Asp - Asp - Tyr - Tyr - Tyr - Gly - Phe - Gly - Cys - Asn - Lys - Phe - Cys - Arg - Pro - Arg - OH