The peptide corresponds to human keratin K18 amino acid 26-38 with an additional C-terminal cysteine. The sequence is the same as that of mouse K18, except that human K18 val28 is replaced by alanine in mouse sequence. Members of the 14-3-3 protein family bind to K18 in a cell cycle and phosphorylation dependent manner. The phosphorylation of K18 ser33 is crucial for the binding of K18 to 14-3-3 protein, and plays a role in the organization and distribution of keratin.
Ref: Ku, NO. et al. EMBO J. 17, 1892 (1998).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Arg - Pro - Val - Ser - Ser - Ala - Ala - pSer - Val - Tyr - Ala - Gly - Ala - Cys - OH