It has been shown that LCMV infection can induce a relatively strong T helper response (at least in C57BL/6 mice), which is almost completely concentrated in the two epitopes GP61–80 and NP309–328, both of which are presented by I-Ab. The LCMV 61-80 peptide preferentially acts as an LCMV T helper epitope, and this epitope appears to be targeted differently by viral cells (lysosomal independent pathway).
Rodriguez, F. et al. J Virol 75, 10421 (2001).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Gly - Leu - Lys - Gly - Pro - Asp - Ile - Tyr - Lys - Gly - Val - Tyr - Gln - Phe - Lys - Ser - Val - Glu - Phe - Asp - OH