Luteinizing Hormone-Releasing Hormone (LH-RH), human
Decapeptide is a hypothalamic hormone that controls the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) in the pituitary gland and promotes mating behavior. It interacts with specific G protein-coupled receptors present in the plasma membrane of pituitary gonadotropin to stimulate the secretion of gonadotropin. In addition to the function of promoting the pituitary gland, it also has an autocrine/paracrine effect on peripheral organs such as prostate, breast and ovary. Luteinizing hormone releasing hormone is not only a neurohormone, but may also act as a neurotransmitter or neuromodulator.
Kiss, J. and B. Halasz, Neurosci 14, 69 (1985); Zheng, L. et al. Neurosci 46, 407 (1992); Collado, B. et al. Intl J Oncol 24, 725 (2004); Hoffman, G. et al. Brain Res 2005 Aug 5; [Epub ahead of print]; Wang, V. et al. Am J Obstet Gynecol 160, 984 (1989).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
Pyr - His - Trp - Ser - Tyr - Gly - Leu - Arg - Pro - Gly - NH2