This peptide is histone 4 acetylation at lysine 12. Based on genome-wide localization studies, it was found that the peptide occupies the promoter region at the transcription start site, especially related to specific promoters, which may drive high-level mRNA transcripts stored in mature sperm. These observations led to the hypothesis that H4K12Ac may be one of the epigenetic markers of developmental genes.
1, Borra, MT. et al. Biochem. 43, 9877 (2004) 2, Paradowska AS. et al. Epigen, 7(9):1057-70 (2012).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Gly - Arg - Gly - Lys - Gly - Gly - Lys - Gly - Leu - Gly - Lys(Ac) - Gly - Gly - Ala - Lys - Arg - His - Arg - Lys - OH