This peptide is histone H4 (1-21), acetylated at lysine 12. The N-terminus contains a C-terminus GG linker, followed by biotinylated lysine. The acetylation of histone H4 plays a crucial role in structural changes, which enhance the binding of transcription factors to recognition sites in nucleosomes. When the peptide purity is greater than 95%, the peptide is dissolved in distilled water at a concentration of 1 mg/ml, and lyophilized again into a powder form.
Vettes-Dadey, M. et al. Embo J 15, 10 (1996).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
Ac - Ser - Gly - Arg - Gly - Lys - Gly - Gly - Lys - Gly - Leu - Gly - Lys(Ac) - Gly - Gly - Ala - Lys - Arg - His - Arg - Lys - Val - Gly - Gly - Lys(Biotin) - OH