This peptide is histone H3 acetylation at lysine 14. Histone lysine acetylation plays an important role in chromatin-directed gene transcription. The brominated master 2 of polybrominated (a chromatin remodeling protein) preferentially recognizes the acetylated lysine of H3.
1, Borra, MT. et al. Biochem. 43:9877 (2004) 2, Charlop-Powers Z. et al. Cell Res. 20:529-538 (2010)
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Arg - Thr - Lys - Gln - Thr - Ala - Arg - Lys - Ser - Thr - Gly - Gly - Lys(Ac) - Ala - Pro - Arg - Lys - Gln - OH