The histone 4 peptide is acetylated at lysine 16. Lysine 16 of H4 seems to be the only target for acetylation. Studies in yeast clearly show that, compared with other histone acetylation sites, the acetylation of H4 lysine 16 is an independent specific function related to gene transcription. It has also been observed that a human histone acetyltransferase complex has a strong specificity for H4K16 in chromatin. RNAi-mediated knockout experiments have shown that it is the main cause of H4 acetylation at lysine 16 in cells .
1, Borra, MT. et al. Biochem. 43, 9877 (2004) 2, Smith ER. et al. Mol Cell Biol, 25(21):9175-9188.
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Gly - Arg - Gly - Lys - Gly - Gly - Lys - Gly - Leu - Gly - Lys - Gly - Gly - Ala - Lys(Ac) - Arg - His - Arg - Lys - OH