This peptide is histone H4 amino acids 1 to 16, acetylated at Lys-16 and the N-terminus. The peptide also contains a GG linker followed by biotinylated lysine. The acetylation of histone H4 causes structural changes, which play a key role in enhancing the binding of transcription factors to specific recognition sites in nucleosomes.
Vettes-Dadey, M. et al. EMBO J 15, 10 (1996).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
Ac - Ser - Gly - Arg - Gly - Lys - Gly - Gly - Lys - Gly - Leu - Gly - Lys - Gly - Gly - Ala - Lys(Ac) - Arg - His - Arg - Lys - Val - Gly - Gly - Lys(Biotin) - OH