This peptide is histone H3 (44-63), acetylated at Lys56. Lys56 acetylation occurs before mitosis and the S phase of mitosis. It persists through DNA damage repair and is catalyzed by the Rtt109-Vps75 histone acetyltransferase (HAT) complex. The loss of acetylated Lys56 in histone H3 is related to spontaneous chromosome breakage during mitosis, indicating that this modification is very important for replication integrity and DNA replication.
Han, J. et al. J Biol Chem 282, 28587 (2007); Schneider, J. et al. J Biol Chem 281, 37270 (2006).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Gly - Thr - Val - Ala - Leu - Arg - Glu - Ile - Arg - Arg - Tyr - Gln - Lys(Ac) - Ser - Thr - Glu - Leu - Leu - Ile - Arg - OH