This peptide is histone H4, amino acids 1 to 21. It is acetylated with a C-terminal GG linker at Lys-8 and N-terminus, followed by biotinylated lysine. The acetylation of histone H4 causes structural changes and enhances the binding of transcription factors to recognition sites in nucleosomes.
Vettes-Dadey, M. et al. EMBO J 15, 10 (1996).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Arg(Me1) - Thr - Lys - Gln - Thr - Ala - Arg - Lys - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - Gly - Gly - Lys(Biotin) - NH2